GOLPH3

the Golgicomplex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgistack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.

Full Name

Golgi Phosphoprotein 3

Function

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.

Biological Process

Asymmetric Golgi ribbon formation Source: CACAO
Cell adhesion molecule production Source: UniProtKB
Cell migration Source: UniProtKB
Cellular response to rapamycin Source: UniProtKB
Gene expression Source: UniProtKB
Glycoprotein biosynthetic process Source: UniProtKB
Golgi organization Source: UniProtKB
Golgi ribbon formation Source: CACAO
Golgi to plasma membrane protein transport Source: UniProtKB
Golgi vesicle budding Source: UniProtKB
Lamellipodium assembly Source: UniProtKB
Leukocyte tethering or rolling Source: UniProtKB
Negative regulation of apoptotic process Source: CACAO
Positive regulation of protein secretion Source: UniProtKB
Positive regulation of TOR signaling Source: UniProtKB
Protein retention in Golgi apparatus Source: UniProtKB
Protein secretion Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central

Cellular Location

Golgi stack membrane; Trans-Golgi network membrane; Endosome; Mitochondrion intermembrane space; Cell membrane. Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes.

PTM

Phosphorylated.