gp120/gp160 (HIV-1)
Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41. Attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. Acts as a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells.
Full Name
Envelope glycoprotein GP120/160
Anti-gp120/gp160 (HIV-1) antibodies
+ Filters
Loading...
CompareTarget: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 3G5
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 3C4
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 36E5
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 12H3
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 1D6
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG2b
Specificity: HIV-1
Clone: 9D1
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG2a
Specificity: HIV-1
Clone: 58B6
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 48C1
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 22F7
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 60C2
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 6D7D4
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 3D9
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 2D8F9
Application*: WB, ELISA, IP, IF
Target: gp120/gp160 (HIV-1)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 2C11B9
Application*: WB, ELISA, IP, IF
More Infomation
Hot products 
-
Human Anti-SARS-CoV-2 Spike Recombinant Antibody (CBC05) (CBMAB-CR005LY)
-
Mouse Anti-BrdU Recombinant Antibody (IIB5) (CBMAB-1038CQ)
-
Mouse Anti-APC Recombinant Antibody (CBYC-A661) (CBMAB-A3036-YC)
-
Mouse Anti-ARHGDIA Recombinant Antibody (CBCNA-009) (CBMAB-R0415-CN)
-
Mouse Anti-dsRNA Recombinant Antibody (2) (CBMAB-D1807-YC)
-
Mouse Anti-ACKR3 Recombinant Antibody (V2-261265) (CBMAB-C1023-LY)
-
Mouse Anti-ADAM12 Recombinant Antibody (V2-179752) (CBMAB-A1114-YC)
-
Mouse Anti-ADAM29 Recombinant Antibody (V2-179787) (CBMAB-A1149-YC)
-
Armenian hamster Anti-CD40 Recombinant Antibody (HM40-3) (CBMAB-C10365-LY)
-
Mouse Anti-AAV-5 Recombinant Antibody (V2-503417) (CBMAB-V208-1369-FY)
-
Mouse Anti-ALB Recombinant Antibody (V2-363290) (CBMAB-S0173-CQ)
-
Mouse Anti-BCL6 Recombinant Antibody (CBYY-0435) (CBMAB-0437-YY)
-
Mouse Anti-BACE1 Recombinant Antibody (61-3E7) (CBMAB-1183-CN)
-
Rat Anti-CD300A Recombinant Antibody (172224) (CBMAB-C0423-LY)
-
Mouse Anti-DES Monoclonal Antibody (440) (CBMAB-AP1857LY)
-
Mouse Anti-DISP2 Monoclonal Antibody (F66A4B1) (CBMAB-1112CQ)
-
Mouse Anti-AK4 Recombinant Antibody (V2-180419) (CBMAB-A1891-YC)
-
Mouse Anti-CRTAM Recombinant Antibody (CBFYC-2235) (CBMAB-C2305-FY)
-
Mouse Anti-CTNND1 Recombinant Antibody (CBFYC-2414) (CBMAB-C2487-FY)
-
Mouse Anti-ACTN4 Recombinant Antibody (V2-6075) (CBMAB-0020CQ)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry