GPR150

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

Full Name

G Protein-Coupled Receptor 150

Function

Orphan receptor.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-3
Helical: 4-24
Cytoplasmic: 25-43
Helical: 44-64
Extracellular: 65-81
Helical: 82-102
Cytoplasmic: 103-162
Helical: 163-183
Extracellular: 184-237
Helical: 238-258
Cytoplasmic: 259-293
Helical: 294-314
Extracellular: 315-334
Helical: 335-355
Cytoplasmic: 356-434