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GTF2E2

GTF2E2 recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Full Name
General Transcription Factor IIE Subunit 2
Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Biological Process
Transcription by RNA polymerase II Source: ARUK-UCL
Transcription initiation from RNA polymerase II promoter Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Trichothiodystrophy 6, non-photosensitive (TTD6):
A form of trichothiodystrophy, a disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD6 patients do not manifest cutaneous photosensitivity. Inheritance pattern has been reported to be autosomal recessive.
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Anti-GTF2E2 antibodies

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Mouse Anti-GTF2E2 Recombinant Antibody (CBLG1-2109) (CBMAB-G5686-LY)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2109
Application*: WB
Datasheet SDS

Mouse Anti-GTF2E2 Recombinant Antibody (8C160) (CBMAB-G5685-LY)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 8C160
Application*: WB
Datasheet SDS

Mouse Anti-GTF2E2 Recombinant Antibody (359C2a) (CBMAB-G5684-LY)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 359C2a
Application*: DB, IC, WB
Datasheet SDS

Mouse Anti-GTF2E2 Recombinant Antibody (CBLG1-274) (CBMAB-G0922-LY)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-274
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-GTF2E2 Recombinant Antibody (CBYJT-1313) (CBMAB-T0329-YJ)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-1313
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-GTF2E2 Recombinant Antibody (CBYJT-1311) (CBMAB-T0327-YJ)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1311
Application*: E, WB
Datasheet SDS

Mouse Anti-GTF2E2 Recombinant Antibody (CBYJT-1310) (CBMAB-T0326-YJ)

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Target: GTF2E2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1310
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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