HCAR2

HCAR2 (Hydroxycarboxylic Acid Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and nicotinic acid receptor activity. An important paralog of this gene is HCAR3.

Full Name

Hydroxycarboxylic Acid Receptor 2

Function

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid> acifran> 5-methyl nicotinic acid = acipimox>> nicotinuric acid = nicotinamide.

Biological Process

Negative regulation of lipid catabolic process Source: UniProtKB
Neutrophil apoptotic process Source: UniProtKB
Positive regulation of adiponectin secretion Source: UniProtKB
Positive regulation of neutrophil apoptotic process Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-33
Helical: 34-54
Cytoplasmic: 55-63
Helical: 64-84
Extracellular: 85-102
Helical: 103-123
Cytoplasmic: 124-142
Helical: 143-163
Extracellular: 164-192
Helical: 193-213
Cytoplasmic: 214-229
Helical: 230-250
Extracellular: 251-273
Helical: 274-294
Cytoplasmic: 295-363