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HGD

Homogentisate 1,2-dioxygenase (HGD) gene mutations are the molecular cause of alkaptonuria, a rare hereditary disorder of the phenylalanine catabolism. The highest expression of HGD is in the prostate, small intestine, colon, and liver. The HGD gene contains 14 exons. Conflicting reports have placed the gene at 3q2, 3q13.3-q21, 3q21-q24, 3q21-q23, or 3q25-q26. [provided by RefSeq]

Full Name

homogentisate 1,2-dioxygenase (homogentisate oxidase)

Biological Process

L-phenylalanine catabolic process Source: GO_Central
Tyrosine catabolic process Source: ProtInc

Cellular Location

Cytosol; Extracellular exosome

Involvement in disease

Alkaptonuria (AKU):
An autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis.

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Anti-HGD antibodies

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Mouse Anti-HGD Recombinant Antibody (3G4) (CBMAB-A3878-LY)

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Target: HGD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G4

Application*: WB, E

Mouse Anti-HGD Recombinant Antibody (1F1) (CBMAB-A3876-LY)

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Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F1

Application*: IF, E

Mouse Anti-HGD Recombinant Antibody (CBFYH-1012) (CBMAB-H1953-FY)

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Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-1012

Application*: E, EC, IF

Mouse Anti-HGD (AA 377-445) Recombinant Antibody (CBFYH-1010) (CBMAB-H1951-FY)

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Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-1010

Application*: E, IF, IP

Mouse Anti-HGD (AA 1-329) Recombinant Antibody (CBFYH-1009) (CBMAB-H1950-FY)

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Target: HGD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1009

Application*: E, IP, WB

Mouse Anti-HGD (AA 377-445) Recombinant Antibody (CBFYH-1008) (CBMAB-H1949-FY)

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Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-1008

Application*: IF, SE, E

Rabbit Anti-HGD Recombinant Antibody (
20D12) (V2LY-0725-LY1335)

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Target: HGD

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 20D12

Application*: E, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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