HGD

Homogentisate 1,2-dioxygenase (HGD) gene mutations are the molecular cause of alkaptonuria, a rare hereditary disorder of the phenylalanine catabolism. The highest expression of HGD is in the prostate, small intestine, colon, and liver. The HGD gene contains 14 exons. Conflicting reports have placed the gene at 3q2, 3q13.3-q21, 3q21-q24, 3q21-q23, or 3q25-q26. [provided by RefSeq]

Full Name

homogentisate 1,2-dioxygenase (homogentisate oxidase)

Biological Process

L-phenylalanine catabolic process Source: GO_Central
Tyrosine catabolic process Source: ProtInc

Cellular Location

Cytosol; Extracellular exosome

Involvement in disease

Alkaptonuria (AKU):
An autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis.

Anti-HGD antibodies

Mouse Anti-HGD Recombinant Antibody (CBFYH-1012) (CBMAB-H1953-FY)

Datasheet

SDS

Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-1012

Application*: E, EC, IF

Mouse Anti-HGD (AA 377-445) Recombinant Antibody (CBFYH-1010) (CBMAB-H1951-FY)

Datasheet

SDS

Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-1010

Application*: E, IF, IP

Mouse Anti-HGD (AA 1-329) Recombinant Antibody (CBFYH-1009) (CBMAB-H1950-FY)

Datasheet

SDS

Target: HGD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1009

Application*: E, IP, WB

Mouse Anti-HGD (AA 377-445) Recombinant Antibody (CBFYH-1008) (CBMAB-H1949-FY)

Datasheet

SDS

Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-1008

Application*: IF, SE, E

Mouse Anti-HGD Recombinant Antibody (3G4) (CBMAB-A3878-LY)

Datasheet

SDS

Target: HGD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G4

Application*: WB, E

Mouse Anti-HGD Recombinant Antibody (1F1) (CBMAB-A3876-LY)

Datasheet

SDS

Target: HGD

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F1

Application*: IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)