Mouse Anti-HGD (AA 377-445) Recombinant Antibody (CBFYH-1008) (CBMAB-H1949-FY)

Bernini, A., Spiga, O., & Santucci, A. (2023). Structure-Function Relationship of Homogentisate 1, 2-dioxygenase: Understanding the Genotype-Phenotype correlations in the Rare Genetic Disease Alkaptonuria. Current Protein & Peptide Science.

Lequeue, S., Neuckermans, J., Nulmans, I., Schwaneberg, U., Vanhaecke, T., & De Kock, J. (2022). A robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1, 2-dioxygenase in the context of alkaptonuria. Scientific Reports, 12(1), 19452.

Tao, L., Deng, C., Ma, M., Zhang, Y., Duan, J., Li, Y., ... & Li, L. (2022). A novel mutation in the homogentisate 1, 2 dioxygenase gene identified in Chinese Hani pediatric patients with Alkaptonuria. Clinica Chimica Acta, 532, 164-171.

Nagalakshmi, V., Lavanya, J., Bhavya, B., Riya, V., Venugopal, B., & Ramesh, A. S. (2022). In-silico profiling of deleterious non synonymous SNPs of homogentisate 1, 2 dioxygenase (HGD) gene for early diagnosis of “Alkaptonuria”. Research Journal of Pharmacy and Technology, 15(9), 3898-3904.

Wilson, P. J., Ranganath, L. R., Bou‐Gharios, G., Gallagher, J. A., & Hughes, J. H. (2021). Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1, 2‐dioxygenase deficiency in the liver is responsible for homogentisic acid‐derived ochronotic pigmentation. JIMD reports, 58(1), 52-60.

Danda, S., Mohan, S., Devaraj, P., Dutta, A. K., Nampoothiri, S., Yesodharan, D., ... & Jebaraj, I. (2020). Founder effects of the homogentisate 1, 2-dioxygenase (HGD) gene in a gypsy population and mutation spectrum in the gene among alkaptonuria patients from India. Clinical Rheumatology, 39, 2743-2749.

Bernini, A., Galderisi, S., Spiga, O., Amarabom, C. O., & Santucci, A. (2020). Transient pockets as mediators of gas molecules routes inside proteins: The case study of dioxygen pathway in homogentisate 1, 2-dioxygenase and its implication in Alkaptonuria development. Computational biology and chemistry, 88, 107356.

Ascher, D. B., Spiga, O., Sekelska, M., Pires, D. E., Bernini, A., Tiezzi, M., ... & Zatkova, A. (2019). Homogentisate 1, 2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU. European Journal of Human Genetics, 27(6), 888-902.

Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J., Sutherland, H., Norman, B. P., ... & Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1, 2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human molecular genetics, 28(23), 3928-3939.

Karmakar, M., Cicaloni, V., Rodrigues, C. H., Spiga, O., Santucci, A., & Ascher, D. B. (2021). HGDiscovery: an online tool providing functional and phenotypic information on novel variants of homogentisate 1, 2-dioxigenase. bioRxiv, 2021-04.

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols