HIP1R

HIP1R (Huntingtin Interacting Protein 1 Related) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include actin binding and phosphatidylinositol binding. An important paralog of this gene is HIP1.

Full Name

huntingtin interacting protein 1 related

Function

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

Biological Process

Actin filament organization Source: GO_Central
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
Apoptotic process Source: InterPro
Clathrin coat assembly Source: GO_Central
Digestive system development Source: Ensembl
Endocytosis Source: GO_Central
Negative regulation of actin filament polymerization Source: ParkinsonsUK-UCL
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: Ensembl
Positive regulation of apoptotic process Source: ParkinsonsUK-UCL
Positive regulation of clathrin coat assembly Source: Ensembl
Positive regulation of epidermal growth factor receptor signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of platelet-derived growth factor receptor-beta signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of protein binding Source: ParkinsonsUK-UCL
Protein stabilization Source: ParkinsonsUK-UCL
Receptor-mediated endocytosis Source: UniProtKB
Regulation of actin cytoskeleton organization Source: ParkinsonsUK-UCL
Regulation of clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
Regulation of endocytosis Source: ParkinsonsUK-UCL
Regulation of gastric acid secretion Source: Ensembl

Cellular Location

Perinuclear region; Endomembrane system; Clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.