HPN

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.
Full Name
hepsin
Alternative Names
Hepsin; Transmembrane Protease Serine 1; EC 3.4.21.106; TMPRSS1; Transmembrane Protease, Serine 1; Testicular Tissue Protein Li 85; Serine Protease Hepsin; EC 3.4.2
Function
Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837).

Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).

Plays a role in the proteolytic processing of ACE2 (PubMed:24227843).

Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Biological Process
Basement membrane disassembly Source: UniProtKB
Cochlea morphogenesis Source: UniProtKB
Detection of mechanical stimulus involved in sensory perception of sound Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: UniProtKB
Pilomotor reflex Source: UniProtKB
Positive regulation by host of viral transcription Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hepatocyte proliferation Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB
Positive regulation of thyroid hormone generation Source: UniProtKB
Potassium ion transmembrane transport Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to thyroid hormone Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane
Topology
Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-417
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Anti-HPN antibodies

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Mouse Anti-HPN Recombinant Antibody (AG84) (V2LY-0524-LY43)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AG84
Application*: E, F
Datasheet SDS

Mouse Anti-HPN Recombinant Antibody (AG83) (V2LY-0524-LY42)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AG83
Application*: E, F, In Vivo, WB
In Vivo Assay
Datasheet SDS

Mouse Anti-HPN (AA 40-417) Recombinant Antibody (CBFYH-1904) (CBMAB-H2910-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1904
Application*: E, WB
Datasheet SDS

Mouse Anti-HPN (AA 38-411) Recombinant Antibody (CBFYH-1902) (CBMAB-H2908-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1902
Application*: E, IH
Datasheet SDS

Mouse Anti-HPN Recombinant Antibody (CBFYH-1901) (CBMAB-H2907-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1901
Application*: IH
Datasheet SDS

Mouse Anti-HPN (AA 163-417) Recombinant Antibody (CBFYH-1900) (CBMAB-H2906-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1900
Application*: E, IH
Datasheet SDS

Mouse Anti-HPN Recombinant Antibody (CBFYH-1899) (CBMAB-H2905-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYH-1899
Application*: E
Datasheet SDS

Mouse Anti-HPN Recombinant Antibody (CBFYH-1898) (CBMAB-H2904-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1898
Application*: IP, WB
Datasheet SDS

Mouse Anti-HPN (AA 166-417) Recombinant Antibody (CBFYH-1897) (CBMAB-H2903-FY)

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Target: HPN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1897
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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