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ICAM1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Full Name
Intercellular Adhesion Molecule 1
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.

(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.

(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Biological Process
Adhesion of symbiont to host Source: BHF-UCL
Cell adhesion Source: BHF-UCL
Cell adhesion mediated by integrin Source: Ensembl
Cellular response to amyloid-beta Source: ARUK-UCL
Cellular response to glucose stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Establishment of endothelial barrier Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Leukocyte cell-cell adhesion Source: BHF-UCL
Leukocyte migration Source: BHF-UCL
Membrane to membrane docking Source: BHF-UCL
Negative regulation of endothelial cell apoptotic process Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Positive regulation of cellular extravasation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Receptor-mediated virion attachment to host cell Source: BHF-UCL
Regulation of leukocyte mediated cytotoxicity Source: BHF-UCL
Regulation of ruffle assembly Source: Ensembl
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: BHF-UCL
T cell antigen processing and presentation Source: Ensembl
T cell extravasation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 28-480
Helical: 481-503
Cytoplasmic: 504-532
PTM
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Anti-ICAM1 antibodies

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Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0492
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0491
Application*: F, FN, IC, IF, C, WB, BL, N
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: mIC2/4 (3C4)
Application*: F, FN, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-112
Application*: F, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Dog
Clone: MEM-111
Application*: WB, F, E, IH, P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: D3.6
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0003
Application*: F, IH, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBRIC2/2
Application*: WB, F, IH, IP, P, FN, C
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A356
Application*: IF, IHC, WB
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A355
Application*: ICC, IF, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A354
Application*: IF, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A353
Application*: ELISA, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A351
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 141032
Application*: WB, F, MC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A350
Application*: FC, IF, IHC, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-I0036
Application*: E
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYY-I0035
Application*: WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0853
Application*: WB, IP, BL, IC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 01
Application*: E, F, IC, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: 1
Application*: P
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I0034
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HM-1
Application*: E, IC, IF, C, P, R, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HA58
Application*: WB, F, IH, P, FN
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P2A4
Application*: E, F, B, IF, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0403
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R6-5-D6
Application*: A, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A361
Application*: ICC, IHC, IP, WB
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A360
Application*: ICC, IF, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A359
Application*: ICC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A358
Application*: ELISA, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A357
Application*: FC, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: LB-2
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb133
Application*: WB, IH, FC
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb132
Application*: WB, IH, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb131
Application*: WB, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: W-CAM-1
Application*: E, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: A349
Application*: FC, IHC, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: A348
Application*: ELISA, IF, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A347
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: F4-31C2
Application*: FA, FC, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP906
Application*: ICC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LT54
Application*: FC, IP
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A352
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF211
Application*: ELISA, IHC, WB, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB459A
Application*: ELISA, WB, ICC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB427A
Application*: ELISA, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB109A
Application*: ELISA, IHC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB260
Application*: IF, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB259
Application*: IF, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB258
Application*: IF, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 84H10
Application*: C, P, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H137
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Pig
Clone: 7H105
Application*: E, F, C, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G12
Application*: E, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D38
Application*: E, F, C, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R6.1
Application*: E
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RR1/1
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R6-5-D6
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0117
Application*: F, C, IA, IF, IP, P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: WK1
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G155
Application*: IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G154
Application*: IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5J278
Application*: FC, IF, IH, N, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1546
Application*: E, FC, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L220
Application*: E, IH, WB
Target: ICAM1
Host: Sheep
Specificity: Human
Clone: 12G2
Application*: E, DB, IH, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.BB.478
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A507
Application*: IF, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P1W16
Application*: F, IH, IF, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: BU74
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H8-2G6
Application*: E, IP, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 1A29
Application*: C, WB, P, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1H4
Application*: C, IC/IF, WB, F, P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5K289
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 10B1815
Application*: F, IH
Target: ICAM1
Host: sheep
Antibody Isotype: IgG
Specificity: Human
Clone: 12G1
Application*: E, DB, C, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13H176
Application*: E, C, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13k24
Application*: C, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13k25
Application*: WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 18
Application*: WB, IC, P, C, E, IP, IF, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 23G12
Application*: P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 28/CD54
Application*: WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 289-1015215.237.15.2
Application*: P, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q709
Application*: E, F, IC, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: 2Q713
Application*: F, IH
Target: ICAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2Q714
Application*: E, F, IC, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q716
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 0.N.147
Application*: IH
Target: ICAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 3E2B
Application*: C, E, FN, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G83
Application*: F, IH, IP, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8J25
Application*: IH, IP
Target: ICAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 3H1550
Application*: E, F, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 0.N.145
Application*: F, IH
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 1.BB.705
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1304
Application*: C, WB, F, P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15.2
Application*: F, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6.5B5
Application*: C, E, P, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 3E2
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1547
Application*: F, IH, IP
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: YN1
Application*: N
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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