IGHE

IGHE (Immunoglobulin Heavy Constant Epsilon) is a Protein Coding gene. Diseases associated with IGHE include Toxocariasis and Allergic Rhinitis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.
Full Name
Immunoglobulin heavy constant epsilon
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Biological Process
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Cellular Location
Secreted; Cell membrane
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Anti-IGHE antibodies

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Rabbit Anti-IGHE Recombinant Antibody (RM122) (CBMAB-BR284LY)

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Target: IGHE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM122
Application*: ELISA
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I1559) (CBMAB-I2729-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1559
Application*: E
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I1554) (CBMAB-I2724-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Guinea Pig, Hamster, Human, Rabbit
Clone: CBYY-I1554
Application*: E
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (BE5) (CBMAB-I1995-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BE5
Application*: F, E
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (XTE4) (CBMAB-I1145-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: XTE4
Application*: WB, E, IC, IF
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I0329) (CBMAB-I0865-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0329
Application*: F, E, IF, IH
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I0308) (CBMAB-I0837-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0308
Application*: F
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I0080) (CBMAB-I0195-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0080
Application*: F, WB, FN
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (E454 (5D5)) (CBMAB-I0194-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: E454 (5D5)
Application*: E
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (E411) (CBMAB-I0193-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: E411
Application*: WB, E
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I0079) (CBMAB-I0191-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0079
Application*: E, IO
Datasheet SDS

Mouse Anti-IGHE Recombinant Antibody (CBYY-I0078) (CBMAB-I0190-YY)

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Target: IGHE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0078
Application*: IO, E
Datasheet SDS

Rat Anti-IGHE Recombinant Antibody (CBLG1-310) (CBMAB-G1079-LY)

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Target: IGHE
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBLG1-310
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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