IVL

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
Full Name
Involucrin
Function
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Biological Process
Isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysineManual Assertion Based On ExperimentTAS:UniProtKB
KeratinizationIEA:UniProtKB-KW
Keratinocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:UniProtKB
Response to UV-BManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm. Constituent of the scaffolding of the cornified envelope.
PTM
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
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Anti-IVL antibodies

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Mouse Anti-IVL Recombinant Antibody (A707) (CBMAB-AP4020LY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Pig
Clone: A707
Application*: IF, IHC, IP, WB
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (A706) (CBMAB-AP4017LY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: A706
Application*: ICC, IHC, WB
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (A705) (CBMAB-AP4009LY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A705
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (SY5) (CBMAB-I1107-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Gorilla, Human, Monkey, Pig, Owl, Rat
Clone: SY5
Application*: WB, IP, E, P, C, F, IF, MC
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (SPM259) (CBMAB-I1092-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM259
Application*: WB, F, E, IF, IP, P, C, MC
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (CBYY-I0048) (CBMAB-I0123-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0048
Application*: F, IF, P
Datasheet SDS

Mouse Ivl ELISA Kit (V2LY-0626-LY2489)

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Target: Ivl
Sensitivity: 0.022 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human IVL ELISA Kit (V2LY-0626-LY1950)

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Target: IVL
Sensitivity: 0.09 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Ivl ELISA Kit (V2LY-0626-LY1610)

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Target: Ivl
Sensitivity: 0.026 ng/mL
Detection Range: 0.05-30 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (SY8) (CBMAB-I1108-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SY8
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (CBYY-I0046) (CBMAB-I0119-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0046
Application*: P, IF
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (IL-9) (CBMAB-I0118-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Pig
Clone: IL-9
Application*: IC, IF, C, P, IP, WB
Datasheet SDS

Mouse Anti-IVL Recombinant Antibody (0.N.341) (CBMAB-I0117-YY)

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Target: IVL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Pig, Rat
Clone: 0.N.341
Application*: E, IF, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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