Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
Full Name
Involucrin
Function
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Biological Process
Isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysineManual Assertion Based On ExperimentTAS:UniProtKB KeratinizationIEA:UniProtKB-KW Keratinocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB Peptide cross-linkingManual Assertion Based On ExperimentIDA:UniProtKB Response to UV-BManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm. Constituent of the scaffolding of the cornified envelope.
PTM
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Loading...
Datasheet