LAMTOR1

Among LAMTOR1's related pathways are Gene Expression and Translational Control. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein-containing complex scaffold activity. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. LAMTOR1 is also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. LAMTOR1 may also play a role in RHOA activation.

Full Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Biological Process

Cellular protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Cholesterol homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Endosomal transportISS:UniProtKB
Endosome organizationISS:UniProtKB
Lysosome localizationISS:UniProtKB
Lysosome organizationISS:UniProtKB
Positive regulation of MAPK cascadeISS:UniProtKB
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of catalytic activityIEA:GOC
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cholesterol effluxManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cholesterol esterificationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cholesterol importManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of receptor recyclingISS:UniProtKB

Cellular Location

Late endosome membrane
Lysosome membrane
Cell membrane