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  • Rabbit Anti-LAMTOR1 Recombinant Antibody (CBYJL-1176)

Rabbit Anti-LAMTOR1 Recombinant Antibody (CBYJL-1176) (CBMAB-L0675-YJ)

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Basic Information

Host Animal
Rabbit
Clone
CBYJL-1176
Application
WB, IP, IHC-P, IF
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Introduction
Among LAMTOR1's related pathways are Gene Expression and Translational Control. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein-containing complex scaffold activity.As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. LAMTOR1 is also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. LAMTOR1 may also play a role in RHOA activation.
Entrez Gene ID
Human55004
Mouse66508
Rat308869
Monkey718249
UniProt ID
HumanQ6IAA8
MouseQ9CQ22
RatQ6P791
MonkeyG7PR11
Alternative Names
C11orf59; PDRO; Ragulator1; p18; p27RF-Rho
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Biological Process
Cellular protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Cholesterol homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Endosomal transportISS:UniProtKB
Endosome organizationISS:UniProtKB
Lysosome localizationISS:UniProtKB
Lysosome organizationISS:UniProtKB
Positive regulation of MAPK cascadeISS:UniProtKB
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of catalytic activityIEA:GOC
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cholesterol effluxManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cholesterol esterificationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cholesterol importManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of receptor recyclingISS:UniProtKB
Cellular Location
Late endosome membrane
Lysosome membrane
Cell membrane

Liu, J. T., Yao, Q. P., Chen, Y., Lv, F., Liu, Z., Bao, H., ... & Qi, Y. X. (2022). Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts. Theranostics, 12(11), 4851.

Wu, B., Wang, Q., Li, B., & Jiang, M. (2022). LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinoma. Carcinogenesis, 43(11), 1059-1070.

Hertel, A., Alves, L. M., Dutz, H., Tascher, G., Bonn, F., Kaulich, M., ... & Bremm, A. (2022). USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Reports, 41(10).

Sun, J., Liu, Y., Hao, X., Lin, W., Su, W., Chiang, E., ... & Bi, X. (2022). LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. The EMBO Journal, 41(5), e108119.

Ying, L., Zhang, M., Ma, X., Si, Y., Li, X., Su, J., ... & Bao, Y. (2021). Macrophage LAMTOR1 deficiency prevents dietary obesity and insulin resistance through inflammation-induced energy expenditure. Frontiers in Cell and Developmental Biology, 9, 672032.

Liu, J. T., Bao, H., Fan, Y. J., Li, Z. T., Yao, Q. P., Han, Y., ... & Qi, Y. X. (2021). Platelet-derived microvesicles promote VSMC dedifferentiation after intimal injury via Src/Lamtor1/mTORC1 Signaling. Frontiers in Cell and Developmental Biology, 9, 744320.

Huang, Q., Gong, Q., Wen, T., Feng, S., Xu, J., Liu, J., ... & Zhu, L. (2020). Loss of LAMTOR1 in pancreatic β‑cells increases glucose‑stimulated insulin secretion in mice. International Journal of Molecular Medicine, 45(1), 23-32.

Lin, C. Y., Nozawa, T., Minowa‐Nozawa, A., Toh, H., Aikawa, C., & Nakagawa, I. (2019). LAMTOR2/LAMTOR1 complex is required for TAX1BP1‐mediated xenophagy. Cellular microbiology, 21(4), e12981.

Sanders, S. S., De Simone, F. I., & Thomas, G. M. (2019). mTORC1 signaling is palmitoylation-dependent in hippocampal neurons and non-neuronal cells and involves dynamic palmitoylation of LAMTOR1 and mTOR. Frontiers in Cellular Neuroscience, 13, 115.

Kimura, T., Kumanogoh, A., & Okada, M. (2018). Roles of Lamtor1 in Macrophages, CD4+ T-cells, and Regulatory T-cells. Critical Reviews™ in Immunology, 38(5).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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