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M6PR

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
Full Name
M6PR
Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Biological Process
Endosome to lysosome transportManual Assertion Based On ExperimentTAS:ProtInc
Lysosomal transportISS:UniProtKB
Protein targeting to lysosomeManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Secretion of lysosomal enzymesIEA:Ensembl
Cellular Location
Lysosome membrane
Topology
Lumenal: 27-185
Helical: 186-210
Cytoplasmic: 211-277
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Anti-M6PR antibodies

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Rabbit Anti-M6PR Recombinant Antibody (CBFYM-0313) (CBMAB-M0378-FY)

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Target: M6PR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYM-0313
Application*: WB, IP, P, F, IF
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBT2419) (V2LY-0625-LY1937)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2419
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBT2335) (V2LY-0625-LY1723)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2335
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBT4690) (V2LY-0625-LY1722)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4690
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBXC-2717) (CBMAB-C0119-CQ)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2717
Application*: WB, E
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBFYM-1243) (CBMAB-M1402-FY)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1243
Application*: E, WB
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBFYM-0357) (CBMAB-M0438-FY)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0357
Application*: F
Datasheet SDS

Mouse Anti-M6PR Recombinant Antibody (CBFYM-0117) (CBMAB-M0135-FY)

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Target: M6PR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0117
Application*: IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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