Sign in or Register   Sign in or Register
  |  

MAP4

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
microtubule-associated protein 4
Function
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Biological Process
Cell divisionManual Assertion Based On ExperimentIMP:MGI
Establishment of spindle orientationManual Assertion Based On ExperimentIMP:MGI
Microtubule cytoskeleton organizationISS:ARUK-UCL
Microtubule slidingManual Assertion Based On ExperimentIMP:MGI
Mitotic spindle organizationManual Assertion Based On ExperimentIMP:MGI
Negative regulation of non-motile cilium assemblyManual Assertion Based On ExperimentIMP:GO_Central
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center
Recruitment to microtubule is inhibited by microtubules polyglutamylation.
PTM
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.

Anti-MAP4 antibodies

Loading...
Target: MAP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 7C9
Application*: WB, E
Target: MAP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18/MAP4
Application*: WB, IF
Target: MAP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1545
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare