MED21

This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants.
Full Name
MED21
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Biological Process
Blastocyst development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl
Cellular Location
Nucleus
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Anti-MED21 antibodies

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Mouse Anti-MED21 Recombinant Antibody (6B6) (CBMAB-A8791-LY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6B6
Application*: WB, E
Datasheet SDS

Mouse Anti-MED21 Recombinant Antibody (5A6) (CBMAB-A8790-LY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A6
Application*: WB, E
Datasheet SDS

Mouse Anti-MED21 Recombinant Antibody (4B5) (CBMAB-A8789-LY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B5
Application*: WB, E
Datasheet SDS

Mouse Anti-MED21 Recombinant Antibody (2D9) (CBMAB-A8788-LY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D9
Application*: WB, E
Datasheet SDS

Mouse Anti-MED21 Recombinant Antibody (3E9) (CBMAB-A8787-LY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E9
Application*: WB, E
Datasheet SDS

Mouse Anti-MED21 Antibody (4F3) (CBMAB-0645-YC)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4F3
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MED21 Antibody (4B5) (CBMAB-0644-YC)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B5
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MED21 Recombinant Antibody (CBFYM-2002) (CBMAB-M2180-FY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2002
Application*: E, WB
Datasheet SDS

Mouse Anti-MED21 (AA 1-145) Recombinant Antibody (CBFYM-0482) (CBMAB-M0610-FY)

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Target: MED21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0482
Application*: E, IC, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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