Mouse Anti-MED21 Recombinant Antibody (4B5) (CBMAB-A8789-LY)

Name: Mouse Anti-MED21 Recombinant Antibody (4B5)
SKU: CBMAB-A8789-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B5

Application

WB, ELISA

Immunogen

SURB7 (AAH08380, 1 a.a. ~ 144 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MED21

Entrez Gene ID

9412

UniProt ID

Q13503

Alternative Names

SRB7; SURB7

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Biological Process

Blastocyst development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl

Cellular Location

Nucleus

Prusty, A., Sharma, S., Malik, N., Kapoor, S., & Tyagi, A. K. (2023). Functional Versatility of Multi-Protein Mediator Complex in Plant Growth and Development. Critical Reviews in Plant Sciences, 1-39.

Richter, W. F., Nayak, S., Iwasa, J., & Taatjes, D. J. (2022). The Mediator complex as a master regulator of transcription by RNA polymerase II. Nature Reviews Molecular Cell Biology, 23(11), 732-749.

Maji, S., Dahiya, P., Waseem, M., Dwivedi, N., Bhat, D. S., Dar, T. H., & Thakur, J. K. (2019). Interaction map of Arabidopsis Mediator complex expounding its topology. Nucleic Acids Research, 47(8), 3904-3920.

Verger, A., Monté, D., & Villeret, V. (2019). Twenty years of Mediator complex structural studies. Biochemical Society Transactions, 47(1), 399-410.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-MED21 Antibody (4B5) (CAT#: CBMAB-0644-YC)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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