NRTN

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016]
Full Name
Neurturin
Function
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Biological Process
MAPK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Nerve developmentIEA:Ensembl
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neural crest cell migrationManual Assertion Based On ExperimentIDA:MGI
Neuron projection developmentManual Assertion Based On ExperimentIDA:MGI
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Involvement in disease
Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
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Anti-NRTN antibodies

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Mouse Anti-NRTN Recombinant Antibody (CBWJN-0671) (CBMAB-N3637-WJ)

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Target: NRTN
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0671
Application*: WB, N
Datasheet SDS

Mouse Anti-NRTN Recombinant Antibody (CBWJN-0665) (CBMAB-N3636-WJ)

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Target: NRTN
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0665
Application*: WB, E, B
Datasheet SDS

Mouse Anti-NRTN Recombinant Antibody (CBWJN-0225) (CBMAB-N3631-WJ)

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Target: NRTN
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBWJN-0225
Application*: E, WB
Datasheet SDS

Mouse Anti-NRTN Recombinant Antibody (32E21) (CBMAB-N3630-WJ)

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Target: NRTN
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 32E21
Application*: WB, E, B
Datasheet SDS

Mouse Anti-NRTN Recombinant Antibody (CBWJN-1558) (CBMAB-N3629-WJ)

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Target: NRTN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1558
Application*: WB
Datasheet SDS

Mouse Anti-NRTN Recombinant Antibody (CBWJN-1557) (CBMAB-N3628-WJ)

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Target: NRTN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1557
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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