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PLAGL1

PLAGL1 is a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM).
Full Name
PLAG1 Like Zinc Finger 1
Function
Acts as a transcriptional activator (PubMed:9722527).
Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Diabetes mellitus, transient neonatal, 1 (TNDM1):
An autosomal dominant form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first month of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.
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Anti-PLAGL1 antibodies

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Mouse Anti-PLAGL1 Recombinant Antibody (CBT3277) (V2LY-0625-LY2840)

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Target: PLAGL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3277
Application*: WB
Datasheet SDS

Mouse Anti-PLAGL1 Recombinant Antibody (CBT2371) (V2LY-0625-LY2839)

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Target: PLAGL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2371
Application*: IH
Datasheet SDS

Mouse Anti-PLAGL1 Recombinant Antibody (8F9D12) (CBMAB-P2021-YC)

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Target: PLAGL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8F9D12
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-PLAGL1 Recombinant Antibody (1E2) (CBMAB-P2019-YC)

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Target: PLAGL1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 1E2
Application*: E, WB
Datasheet SDS

Mouse Anti-PLAGL1 Recombinant Antibody (CBWJZ-005) (CBMAB-Z0011-WJ)

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Target: PLAGL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJZ-005
Application*: WB, IP, IF, P, E
Datasheet SDS

Rabbit Anti-PLAGL1 Recombinant Antibody (BA0337) (CBMAB-0660CQ)

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Target: PLAGL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0337
Application*: F, WB
Datasheet SDS

Mouse Anti-PLAGL1 Recombinant Antibody (8D8C5) (CBMAB-0659CQ)

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Target: PLAGL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D8C5
Application*: WB, P
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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