PLAGL1

PLAGL1 is a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM).

Full Name

PLAG1 Like Zinc Finger 1

Function

Acts as a transcriptional activator (PubMed:9722527).
Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Diabetes mellitus, transient neonatal, 1 (TNDM1):
An autosomal dominant form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first month of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.

Anti-PLAGL1 antibodies

Mouse Anti-PLAGL1 Recombinant Antibody (CBWJZ-005) (CBMAB-Z0011-WJ)

Datasheet

SDS

Target: PLAGL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJZ-005

Application*: WB, IP, IF, P, E

Rabbit Anti-PLAGL1 Recombinant Antibody (BA0337) (CBMAB-0660CQ)

Datasheet

SDS

Target: PLAGL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: BA0337

Application*: F, WB

Mouse Anti-PLAGL1 Recombinant Antibody (8D8C5) (CBMAB-0659CQ)

Datasheet

SDS

Target: PLAGL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8D8C5

Application*: WB, P

Mouse Anti-PLAGL1 Recombinant Antibody (8F9D12) (CBMAB-P2021-YC)

Datasheet

SDS

Target: PLAGL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 8F9D12

Application*: E, WB, P, IF, IC, F

Mouse Anti-PLAGL1 Recombinant Antibody (1E2) (CBMAB-P2019-YC)

Datasheet

SDS

Target: PLAGL1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: 1E2

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)