PROKR1

PROKR1 is a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation.

Full Name

Prokineticin Receptor 1

Function

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Biological Process

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-62
Helical: 63-83
Cytoplasmic: 84-98
Helical: 99-119
Extracellular: 120-146
Helical: 147-167
Cytoplasmic: 168-180
Helical: 181-201
Extracellular: 202-232
Helical: 233-253
Cytoplasmic: 254-282
Helical: 283-303
Extracellular: 304-322
Helical: 323-343
Cytoplasmic: 344-393