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RASA3

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq]

Full Name

RAS p21 protein activator 3

Function

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Biological Process

Biological Process negative regulation of Ras protein signal transductionIEA:InterPro
Biological Process regulation of GTPase activityIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

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Anti-RASA3 antibodies

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Mouse Anti-RASA3 Recombinant Antibody (CBLG1-3243) (CBMAB-G6531-LY)

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Target: RASA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3243

Application*: WB

Mouse Anti-RASA3 Recombinant Antibody (GP-3) (CBMAB-R1467-CN)

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Target: RASA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: GP-3

Application*: WB, E, ICC

Mouse Anti-RASA3 Recombinant Antibody (CBFYH-2726) (CBMAB-H0759-FY)

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Target: RASA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: CBFYH-2726

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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