SIN3A

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

SIN3 Transcription Regulator Family Member A

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).
Required for cortical neuron differentiation and callosal axon elongation (By similarity).

Biological Process activation of innate immune responseManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process agingIEA:Ensembl
Biological Process cellular response to dopamineIEA:Ensembl
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process cerebral cortex neuron differentiationISS:UniProtKB
Biological Process DNA replicationIEA:Ensembl
Biological Process hematopoietic progenitor cell differentiationIEA:Ensembl
Biological Process histone deacetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process negative regulation of apoptotic processIEA:Ensembl
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of circadian rhythmISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of histone H3-K27 acetylationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of protein localization to nucleusManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of G2/M transition of mitotic cell cycleIEA:Ensembl
Biological Process positive regulation of heterochromatin assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of neuron differentiationISS:UniProtKB
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein deacetylationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein localizationIEA:Ensembl
Biological Process regulation of axon extensionISS:UniProtKB
Biological Process regulation of hormone levelsIEA:Ensembl
Biological Process regulation of transcription from RNA polymerase II promoter in response to oxidative stressIEA:Ensembl
Biological Process response to methylglyoxalIEA:Ensembl
Biological Process rhythmic processIEA:UniProtKB-KW

Nucleus
Nucleus, nucleolus
Recruited to the nucleolus by SAP30L.

Witteveen-Kolk syndrome (WITKOS):
An autosomal dominant syndrome characterized by global developmental delay, mild to severe intellectual disability, and facial dysmorphism. Additional features include short stature, microcephaly, joint hypermotility, and small hands and feet with digital abnormalities. Brain imaging shows dilated ventricles, thin corpus callosum and, in some cases, dysgyria or polymicrogyria.

SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.