STXBP3

STXBP3 is required for recycling of RAB11A-containing endosomes to the plasma membrane.

Full Name

SYNTAXIN BINDING PROTEIN 3

Function

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Biological Process

Biological Process brain developmentIEA:Ensembl
Biological Process cellular glucose homeostasisIEA:Ensembl
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process insulin secretionIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of calcium ion-dependent exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of glucose importIEA:Ensembl
Biological Process neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neutrophil degranulationManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process platelet aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein to membrane dockingIEA:Ensembl
Biological Process response to insulinIEA:Ensembl
Biological Process vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytosol
Cell membrane
In platelets, predominantly cytosolic. Low amounts membrane-associated.

PTM

Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.