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SULT1E1

Estrogen sulfotransferase, also knownas Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 andST1E1, is a cytoplasm enzyme which belongs to the sulfotransferase 1family. Sulfotransferase enzymes catalyze the sulfate conjugation of manyhormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolicenzymes are different in their tissue distributions and substratespecificities. SULT1E1 may control the level of the estrogen receptor bysulfurylating free estradiol. SULT1E1 maximally sulfates beta-estradiol andestrone at concentrations of 20 nM. SULT1E1 also sulfatesdehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin,diethylstilbesterol and 1-naphthol, at significantly higher concentrations;however, cortisol, testosterone and dopamine are not sulfated. SULT1E1 is a keyenzyme in estrogen homeostasis. It plays a central role in the prevention anddevelopment of human disease.
Full Name
SULT1E1
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110).
Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875).
Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process estrogen catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process estrogen metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of fat cell differentiationManual Assertion Based On ExperimentIMP:CACAO
Biological Process steroid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm, cytosol

Anti-SULT1E1 antibodies

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Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0564
Application*: WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11BA36
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA37
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA38
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1662
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5706
Application*: E
Target: SULT1E1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0846
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0847
Application*: IF, P
Target: SULT1E1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1082
Application*: ED
Target: SULT1E1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1108
Application*: EC
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: EST.1
Application*: IC, IF, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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