SULT1E1
Estrogen sulfotransferase, also knownas Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 andST1E1, is a cytoplasm enzyme which belongs to the sulfotransferase 1family. Sulfotransferase enzymes catalyze the sulfate conjugation of manyhormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolicenzymes are different in their tissue distributions and substratespecificities. SULT1E1 may control the level of the estrogen receptor bysulfurylating free estradiol. SULT1E1 maximally sulfates beta-estradiol andestrone at concentrations of 20 nM. SULT1E1 also sulfatesdehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin,diethylstilbesterol and 1-naphthol, at significantly higher concentrations;however, cortisol, testosterone and dopamine are not sulfated. SULT1E1 is a keyenzyme in estrogen homeostasis. It plays a central role in the prevention anddevelopment of human disease.
Full Name
SULT1E1
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110).
Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875).
Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875).
Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process estrogen catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process estrogen metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of fat cell differentiationManual Assertion Based On ExperimentIMP:CACAO
Biological Process steroid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process estrogen catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process estrogen metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of fat cell differentiationManual Assertion Based On ExperimentIMP:CACAO
Biological Process steroid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasm, cytosol
View more
Anti-SULT1E1 antibodies
+ Filters
Loading...
CompareTarget: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: EST.1
Application*: IC, IF, P, WB
Target: SULT1E1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1108
Application*: EC
Target: SULT1E1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1082
Application*: ED
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0847
Application*: IF, P
Target: SULT1E1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0846
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5706
Application*: E
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0564
Application*: WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1662
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA38
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA37
Application*: E, WB
Target: SULT1E1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11BA36
Application*: E, WB
Target: SULT1E1
Specificity: Human
More Infomation
Hot products 
-
Mouse Anti-ENO1 Recombinant Antibody (8G8) (CBMAB-E1329-FY)
-
Mouse Anti-CCDC25 Recombinant Antibody (CBLC132-LY) (CBMAB-C9786-LY)
-
Mouse Anti-BACE1 Recombinant Antibody (CBLNB-121) (CBMAB-1180-CN)
-
Mouse Anti-AQP2 Recombinant Antibody (G-3) (CBMAB-A3359-YC)
-
Mouse Anti-ATP5F1A Recombinant Antibody (51) (CBMAB-A4043-YC)
-
Mouse Anti-BLNK Recombinant Antibody (CBYY-0623) (CBMAB-0626-YY)
-
Rat Anti-CD34 Recombinant Antibody (MEC 14.7) (CBMAB-C10196-LY)
-
Mouse Anti-GLP1R Recombinant Antibody (4F3) (CBMAB-G0521-LY)
-
Mouse Anti-CEMIP Recombinant Antibody (3C12) (CBMAB-K0296-LY)
-
Mouse Anti-ARSA Recombinant Antibody (CBYC-A799) (CBMAB-A3679-YC)
-
Human Anti-SARS-CoV-2 Spike Recombinant Antibody (CBC05) (CBMAB-CR005LY)
-
Rat Anti-4-1BB Recombinant Antibody (V2-1558) (CBMAB-0953-LY)
-
Mouse Anti-8-oxoguanine Recombinant Antibody (V2-7697) (CBMAB-1869CQ)
-
Mouse Anti-AMIGO2 Recombinant Antibody (CBYY-C0756) (CBMAB-C2192-YY)
-
Mouse Anti-ALPL Antibody (B4-78) (CBMAB-1009CQ)
-
Mouse Anti-ARID3A Antibody (A4) (CBMAB-0128-YC)
-
Rabbit Anti-AKT2 (Phosphorylated S474) Recombinant Antibody (V2-556130) (PTM-CBMAB-0605LY)
-
Mouse Anti-CD19 Recombinant Antibody (CBXC-1224) (CBMAB-C1491-CQ)
-
Mouse Anti-AKR1C3 Recombinant Antibody (V2-12560) (CBMAB-1050-CN)
-
Rabbit Anti-CBL Recombinant Antibody (D4E10) (CBMAB-CP0149-LY)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry