SYCP1

Full Name

Synaptonemal complex protein 1

Function

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chiasma assemblyIBA:GO_Central1 Publication
Biological Process homologous chromosome pairing at meiosisISS:UniProtKB
Biological Process lateral element assemblyIBA:GO_Central1 Publication
Biological Process meiotic DNA repair synthesisIBA:GO_Central1 Publication
Biological Process protein homotetramerizationIDA:UniProtKB1 Publication
Biological Process reciprocal meiotic recombinationISS:UniProtKB
Biological Process regulation of protein localizationIEA:Ensembl
Biological Process sperm DNA condensationIEA:Ensembl
Biological Process spermatogenesisTAS:ProtInc1 Publication
Biological Process synaptonemal complex assemblyISS:UniProtKB

Cellular Location

Nucleus
Chromosome
Chromosome, centromere
In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity).
Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity).