SYT7

Synaptotagmins, such as SYT7, are brain-specific calcium-dependent phospholipid-binding proteins that play a role in synaptic exocytosis and neurotransmitter release. See MIM 600782.[supplied by OMIM

synaptotagmin VII

Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory and synaptic vesicles through Ca2+ and phospholipid binding to the C2 domain (By similarity).
Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
SYT7 binds Ca2+ with high affinity and slow kinetics compared to other synaptotagmins (By similarity).
Involved in Ca2+-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594).
Ca2+-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity).
Ca2+-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity).
In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca2+-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535).
Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity).
Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca2+ into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity).
Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity).
May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca2+ and by forming a complex with calmodulin (By similarity).
Also acts as a regulator of Ca2+-dependent insulin and glucagon secretion in beta-cells (By similarity).
Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity).
Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).

Biological Process calcium ion regulated lysosome exocytosisISS:UniProtKB
Biological Process calcium ion-regulated exocytosis of neurotransmitterISS:UniProtKB
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process phagocytosisISS:UniProtKB
Biological Process phagosome-lysosome fusionISS:UniProtKB
Biological Process plasma membrane repairISS:UniProtKB
Biological Process positive regulation of calcium ion-dependent exocytosisIEA:Ensembl
Biological Process regulation of bone remodelingISS:UniProtKB
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of glucagon secretionISS:UniProtKB
Biological Process regulation of insulin secretionISS:UniProtKB
Biological Process regulation of phagocytosisISS:UniProtKB
Biological Process short-term synaptic potentiationISS:UniProtKB
Biological Process synaptic vesicle recyclingISS:UniProtKB
Biological Process vesicle-mediated cholesterol transportISS:UniProtKB
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication

Cell membrane
Presynaptic cell membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Lysosome membrane
Cytoplasmic vesicle, phagosome membrane
Peroxisome membrane
Cytoplasmic vesicle, secretory vesicle membrane
Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63.

Vesicular: 1-16
Helical: 17-37
Cytoplasmic: 38-403

Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.