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TPM2

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Full Name
tropomyosin 2 (beta)
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Biological Process
Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process regulation of ATP-dependent activity Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Associates with F-actin stress fibers.
Involvement in disease
Nemaline myopathy 4 (NEM4):
A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life.
Arthrogryposis, distal, 1A (DA1A):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.
Cap myopathy 2 (CAPM2):
A rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and non-progressive or slowly progressive muscle weakness. Respiratory problems are common.
Arthrogryposis, distal, 2B4 (DA2B4):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.
PTM
Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).

Anti-TPM2 antibodies

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Target: TPM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Ferret, Human, Rodent
Clone: CG1
Application*: F, B, IF, IH, IP, WB
Target: TPM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C8
Application*: WB, E
Target: TPM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Rabbit, Rat
Clone: CBYJT-4344
Application*: IF, IH, IP, WB
Target: TPM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Rat
Clone: CBYJT-4345
Application*: WB
Target: TPM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken, Human, Mouse, Rat
Clone: CBYJT-4346
Application*: IC, IF, IH, WB
Target: TPM2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4347
Application*: WB, IP, IF, P, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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