TUSC2

TUSC2 is a highly conserved lung cancer candidate gene.

Full Name

Tumor Suppressor Candidate 2

Function

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell maturation Source:Ensembl
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process natural killer cell differentiation Source:Ensembl
Biological Process negative regulation of interleukin-17 production Source:Ensembl
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:Ensembl
Biological Process phagocytosis Source:Ensembl
Biological Process positive regulation of interleukin-10 production Source:Ensembl
Biological Process regulation of mitochondrial membrane potential Source:GO_Central1 Publication
Biological Process regulation of reactive oxygen species metabolic process Source:Ensembl

Cellular Location

Mitochondrion

PTM

Myristoylation is required for tumor suppressor activity.