UBE2L6

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
Full Name
Ubiquitin Conjugating Enzyme E2 L6
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Biological Process
Biological Process ISG15-protein conjugation Source:GO_Central1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
ubiquitin ligase complex
PTM
ISGylated.
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Anti-UBE2L6 antibodies

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Mouse Anti-UBE2L6 Antibody (12BA34) (CBMAB-1709CQ)

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12BA34
Application*: E, WB
Datasheet SDS

Mouse Anti-UBE2L6 Antibody (12BA33) (CBMAB-1708CQ)

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12BA33
Application*: E, WB
Datasheet SDS

Mouse Anti-UBE2L6 Antibody (12BA32) (CBMAB-1707CQ)

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA32
Application*: E, WB
Datasheet SDS

UBE2L6 Matched Antibody Pair (1292) (APMAB-1292LY)

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Target: UBE2L6
Specificity: Human
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Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-133) (CBMAB-U0133-FY)

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-133
Application*: WB
Datasheet SDS

Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-132) (CBMAB-U0132-FY)

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYU-132
Application*: WB, E, IH, P
Datasheet SDS

Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-131) (CBMAB-U0131-FY)

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYU-131
Application*: SE, E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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