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UBE2L6

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
Full Name
Ubiquitin Conjugating Enzyme E2 L6
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Biological Process
Biological Process ISG15-protein conjugation Source:GO_Central1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
ubiquitin ligase complex
PTM
ISGylated.

Anti-UBE2L6 antibodies

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Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA32
Application*: E, WB
Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12BA33
Application*: E, WB
Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12BA34
Application*: E, WB
Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYU-131
Application*: SE, E, WB
Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYU-132
Application*: WB, E, IH, P
Target: UBE2L6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-133
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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