Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-131) (CBMAB-U0131-FY)

Name: Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-131)
SKU: CBMAB-U0131-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYU-131

Application

S-ELISA, ELISA, WB

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 kD.

Specificity

Human

Antibody Isotype

IgG1, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-153

More Infomation

Target

Full Name

Ubiquitin Conjugating Enzyme E2 L6

Introduction

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. It catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins and functions in the E6/E6-AP-induced ubiquitination of p53/TP53. It may promote ubiquitination and subsequent proteasomal degradation of FLT3. Among its related pathways are Proteolysis_Putative ubiquitin pathway and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.

Entrez Gene ID

9246

UniProt ID

O14933

Alternative Names

ubiquitin-conjugating enzyme E2L 6; UBCH8; Retinoic acid-induced gene B protein; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6; RIG-B; EC 6.3.2.19; retinoic acid induced gene B protein; ubiquitin/ISG15-conjugating enzyme E2 L6; UbcH8

Function

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Biological Process

Biological Process ISG15-protein conjugation Source:GO_Central1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication

Cellular Location

cytosol
nucleoplasm
nucleus
ubiquitin ligase complex

PTM

ISGylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

UBE2L6 Matched Antibody Pair (1292) (CAT#: APMAB-1292LY)

Related Products

UBE2L6 Matched Antibody Pair (1292) (CAT#: APMAB-1292LY)

Mouse Anti-UBE2L6 Antibody (12BA32) (CAT#: CBMAB-1707CQ)

Mouse Anti-UBE2L6 Antibody (12BA34) (CAT#: CBMAB-1709CQ)

Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-133) (CAT#: CBMAB-U0133-FY)

Mouse Anti-UBE2L6 Antibody (12BA33) (CAT#: CBMAB-1708CQ)

Mouse Anti-UBE2L6 Recombinant Antibody (CBFYU-132) (CAT#: CBMAB-U0132-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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