USP22

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Full Name
ubiquitin specific peptidase 22
Function
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process embryo development ending in birth or egg hatching Source:UniProtKB1 Publication
Biological Process histone deubiquitination Source:UniProtKB2 Publications
Biological Process histone H3 acetylation Source:ComplexPortal1 Publication
Biological Process histone ubiquitination Source:UniProtKB1 Publication
Biological Process monoubiquitinated histone deubiquitination Source:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitination Source:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:ComplexPortal2 Publications
Biological Process regulation of RNA splicing Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
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Anti-USP22 antibodies

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Rabbit Anti-USP22 Recombinant Antibody (
18H6) (V2LY-0725-LY1358)

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Target: USP22
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 18H6
Application*: E, WB, IF, F
Datasheet SDS

Rabbit Anti-USP22 Recombinant Antibody (
18E3) (V2LY-0725-LY928)

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Target: USP22
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 18E3
Application*: E, IF, F
Datasheet SDS

Mouse Anti-USP22 Recombinant Antibody (CBXU-088) (CBMAB-U0189-CQ)

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Target: USP22
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXU-088
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-USP22 Recombinant Antibody (CBXU-086) (CBMAB-U0188-CQ)

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Target: USP22
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXU-086
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-USP22 Recombinant Antibody (CBXU-043) (CBMAB-U0158-CQ)

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Target: USP22
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXU-043
Application*: WB
Datasheet SDS

Rabbit Anti-USP22 Recombinant Antibody (CBXU-032) (CBMAB-U0148-CQ)

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Target: USP22
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXU-032
Application*: WB, IP, F, IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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