WSB1

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Full Name

WD repeat and SOCS box-containing 1

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Biological Process

Biological Process intracellular signal transduction Source:InterPro
Biological Process protein aggregate center assembly Source:Ensembl
Biological Process protein K27-linked ubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:GO_Central1 Publication

Cellular Location

cytosol

Anti-WSB1 antibodies

Mouse Anti-WSB1 Recombinant Antibody (3E10) (CBMAB-W0095-WJ)

Datasheet

SDS

Target: WSB1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3E10

Application*: E

Mouse Anti-WSB1 Recombinant Antibody (K5P6A5) (CBMAB-W0331-WJ)

Datasheet

SDS

Target: WSB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: K5P6A5

Application*: WB, E, IH

Recombinant Mouse Anti-WSB1 Recombinant Antibody (K5P2H10) (CBMAB-XB1231-YC)

Datasheet

SDS

Target: WSB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: K5P2H10

Application*: E, IH, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)