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WSB1

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Full Name

WD repeat and SOCS box-containing 1

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Biological Process

Biological Process intracellular signal transduction Source:InterPro
Biological Process protein aggregate center assembly Source:Ensembl
Biological Process protein K27-linked ubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:GO_Central1 Publication

Cellular Location

cytosol

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Anti-WSB1 antibodies

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Recombinant Mouse Anti-WSB1 Recombinant Antibody (K5P2H10) (CBMAB-XB1231-YC)

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Target: WSB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: K5P2H10

Application*: E, IH, WB

Mouse Anti-WSB1 Recombinant Antibody (K5P6A5) (CBMAB-W0331-WJ)

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Target: WSB1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: K5P6A5

Application*: WB, E, IH

Mouse Anti-WSB1 Recombinant Antibody (3E10) (CBMAB-W0095-WJ)

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Target: WSB1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3E10

Application*: E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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