ALAD

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin a

Aminolevulinate Dehydratase

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Cellular response to interleukin-4 Source: Ensembl
Cellular response to lead ion Source: Ensembl
Heme biosynthetic process Source: UniProtKB
Negative regulation of proteasomal protein catabolic process Source: CAFA
Neutrophil degranulation Source: Reactome
Protein homooligomerization Source: UniProtKB
Protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Response to activity Source: Ensembl
Response to aluminum ion Source: Ensembl
Response to amino acid Source: Ensembl
Response to arsenic-containing substance Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to cobalt ion Source: Ensembl
Response to drug Source: Ensembl
Response to ethanol Source: Ensembl
Response to fatty acid Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to herbicide Source: Ensembl
Response to hypoxia Source: Ensembl
Response to ionizing radiation Source: Ensembl
Response to iron ion Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mercury ion Source: Ensembl
Response to methylmercury Source: Ensembl
Response to oxidative stress Source: Ensembl
Response to platinum ion Source: Ensembl
Response to selenium ion Source: Ensembl
Response to vitamin B1 Source: Ensembl
Response to vitamin E Source: Ensembl
Response to zinc ion Source: Ensembl

Cytosol; Extracellular exosome; Extracellular region; Nucleus; Ficolin-1-rich granule lumen; Secretory granule lumen

Acute hepatic porphyria (AHEPP): A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AHP is characterized by attacks of gastrointestinal disturbances, abdominal colic, paralyses and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors.