ALDH3B1

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene is highly expressed in kidney and lung. The functional significance of this gene as well as the cellular localization of its product are presently unknown. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

aldehyde dehydrogenase 3 family, member B1

Function

Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920). Metabolizes also benzaldehyde (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). May not metabolize short chain aldehydes. Can use both NADP+ and NAD+ as electron acceptor (PubMed:17382292). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292).

Biological Process

Alcohol metabolic process Source: ProtInc
Aldehyde catabolic process Source: MGI
Cellular response to oxidative stress Source: MGI
Ethanol catabolic process Source: UniProtKB-UniPathway
Lipid metabolic process Source: ProtInc
Neutrophil degranulation Source: Reactome
Sphingolipid biosynthetic process Source: Reactome

Cellular Location

Cell membrane. Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

PTM

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.