ATRIP (Phospho-Ser224)

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Full Name

ATR Interacting Protein

Function

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

Biological Process

DNA damage checkpoint Source: GO_Central
DNA repair Source: GO_Central
DNA replication Source: Reactome
Interstrand cross-link repair Source: Reactome
Regulation of signal transduction by p53 class mediator Source: Reactome

Cellular Location

Nucleus. Redistributes to discrete nuclear foci upon DNA damage.