AVPR1B

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

Full Name

Arginine Vasopressin Receptor 1B

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
(Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, may recognize and internalize the complex formed by AVP/Arg-vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through DNM2/dynamin 2-dependent endocytosis.

Biological Process

Activation of phospholipase C activity Source: ARUK-UCL
G protein-coupled receptor signaling pathway Source: ARUK-UCL
Positive regulation of arachidonic acid secretion Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Positive regulation of inositol phosphate biosynthetic process Source: ARUK-UCL
Positive regulation of MAPK cascade Source: ARUK-UCL
Positive regulation of phospholipase A2 activity Source: ARUK-UCL
Positive regulation of vasoconstriction Source: GO_Central
Regulation of cell population proliferation Source: ARUK-UCL
Regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
Transport across blood-brain barrier Source: ARUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 1-35 aa
Helical: 36-59 aa
Cytoplasmic: 60-71 aa
Helical: 72-93 aa
Extracellular: 94-108 aa
Helical: 109-130 aa
Cytoplasmic: 131-151 aa
Helical: 152-173 aa
Extracellular: 174-201 aa
Helical: 202-222 aa
Cytoplasmic: 223-283 aa
Helical: 284-303 aa
Extracellular: 304-321 aa
Helical: 322-341 aa
Cytoplasmic: 342-424 aa