BRD3

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

Full Name

Bromodomain Containing 3

Function

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114).
Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).

Biological Process

Chromatin organization Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus. Detected on chromatin.

Involvement in disease

A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein.

Anti-BRD3 antibodies

Mouse Anti-BRD3 Recombinant Antibody (CBYY-2148) (CBMAB-2497-YY)

Datasheet

SDS

Target: BRD3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-2148

Application*: E, WB

Mouse Anti-BRD3 Recombinant Antibody (CBYY-1947) (CBMAB-2296-YY)

Datasheet

SDS

Target: BRD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1947

Application*: DB, F, IC, IF, IP, WB

Mouse Anti-BRD3 Recombinant Antibody (CBYY-1779) (CBMAB-2128-YY)

Datasheet

SDS

Target: BRD3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-1779

Application*: E, IH, WB

Datasheet

SDS

Target: BRD3

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)