CADM1

CADM1 (Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CADM1 include Lung Cancer and Retroperitoneal Fibrosis. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding. An important paralog of this gene is CADM2.

Full Name

Cell Adhesion Molecule 1

Function

Mediates homophilic cell-cell adhesion in a Ca2+-independent manner (PubMed:22438059, PubMed:12050160).
Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner (By similarity).
Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).
In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536).
CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059).
By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity).
Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity).
Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity).
May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity).
May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity).
Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973).
May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246).

Biological Process

Adherens junction organization Source: Reactome
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Cell recognition Source: UniProtKB
Detection of stimulus Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Immune system process Source: UniProtKB-KW
Multicellular organism development Source: UniProtKB-KW
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Spermatogenesis Source: UniProtKB-KW
Susceptibility to natural killer cell mediated cytotoxicity Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane; Synapse. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.

Topology

Extracellular: 45-374 aa
Helical: 375-395 aa
Cytoplasmic: 396-442 aa

PTM

Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.