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CD163

CD163 (CD163 Molecule) is a Protein Coding gene. Diseases associated with CD163 include Rosai-Dorfman Disease and Non-Langerhans-Cell Histiocytosis. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is CD163L1.
Full Name
CD163 Molecule
Function
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Biological Process
Acute-phase response Source: UniProtKB-KW
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Secreted; Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
Topology
Extracellular: 42-1050
Helical: 1051-1071
Cytoplasmic: 1072-1156
PTM
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
Phosphorylated.

Anti-CD163 antibodies

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Mouse Anti-CD163 Recombinant Antibody (CBFYA-0209) (CBMAB-X0297-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYA-0209
Application*: F, C, IF, IP, P, WB

Mouse Anti-CD163 Recombinant Antibody (CBFYA-0147) (CBMAB-X0210-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYA-0147
Application*: F, C, FN, IF, IP, WB

Mouse Anti-CD163 Recombinant Antibody (CBXC-1885) (CBMAB-C5501-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1885
Application*: IH, IF, P

Mouse Anti-CD163 Recombinant Antibody (MRQ-26) (CBMAB-C5500-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MRQ-26
Application*: IH

Rabbit Anti-CD163 Recombinant Antibody (K20-T) (CBMAB-C5498-CQ)

Datasheet SDS
Target: CD163
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: K20-T
Application*: IH, IF, P, C

Mouse Anti-CD163 Recombinant Antibody (RM3/1) (CBMAB-C5497-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RM3/1
Application*: WB, F, IH, IF, IP, C

Mouse Anti-CD163 Recombinant Antibody (CBXC-2023) (CBMAB-C5495-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2023
Application*: WB, IH, IF

Mouse Anti-CD163 Recombinant Antibody (CBXC-1922) (CBMAB-C5494-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1922
Application*: WB, IH, IF

Mouse Anti-CD163 Recombinant Antibody (CBXC-1016) (CBMAB-C1278-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1016
Application*: F

Mouse Anti-CD163 Recombinant Antibody (GHI/61) (CBMAB-C0676-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: GHI/61
Application*: WB, F

Mouse Anti-CD163 Recombinant Antibody (EDHu-1) (CBMAB-C0650-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Cattle, Guinea Pig, Monkey, Sheep
Clone: EDHu-1
Application*: WB, F, E, IH, IF, P, C, IA

Mouse Anti-CD163 Recombinant Antibody (CBXC-3003) (CBMAB-C0319-CQ)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-3003
Application*: WB, F, IH, P

Mouse Anti-CD163 Recombinant Antibody (CBFYC-1123) (CBMAB-C1181-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-1123
Application*: F, IF, IH, IP, WB

Mouse Anti-CD163 Recombinant Antibody (CBFYC-1122) (CBMAB-C1180-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBFYC-1122
Application*: F, IF, IH, IP, WB

Mouse Anti-CD163 Recombinant Antibody (CBFYC-1121) (CBMAB-C1179-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1121
Application*: ED

Mouse Anti-CD163 Recombinant Antibody (CBFYC-1119) (CBMAB-C1177-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-1119
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (CBFYC-1118) (CBMAB-C1176-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1118
Application*: WB, P, IF

Mouse Anti-CD163 Recombinant Antibody (CBFYC-0514) (CBMAB-C0565-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBFYC-0514
Application*: F, C, IP, WB

Mouse Anti-CD163 Recombinant Antibody (CBFYC-0444) (CBMAB-C0490-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0444
Application*: F

Mouse Anti-CD163 Recombinant Antibody (CBFYC-0192) (CBMAB-C0215-FY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-0192
Application*: F

Mouse Anti-CD163 Recombinant Antibody (2A10/11) (CBMAB-C0814-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 2A10/11
Application*: F, C, IP, WB

Mouse Anti-CD163 Recombinant Antibody (10B839) (CBMAB-C0171-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 10B839
Application*: F, IF, IH, IP, WB

Rabbit Anti-CD163 Recombinant Antibody (CAP379) (CBMAB-AP946LY)

Datasheet SDS
Target: CD163
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP379
Application*: ELISA, FC, IHC

Mouse Anti-CD163 Recombinant Antibody (CB101A) (CBMAB-CA101LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB101A
Application*: ELISA, IHC

Mouse Anti-CD163 Recombinant Antibody (CB041) (CBMAB-CS041LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB041
Application*: IF, FC

Rabbit Anti-CD163 Recombinant Antibody (RM371) (CBMAB-BR077LY)

Datasheet SDS
Target: CD163
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM371
Application*: IHC, WB

Rabbit Anti-CD163 Recombinant Antibody (CBR087G) (CBMAB-BT011LY)

Datasheet SDS
Target: CD163
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR087G
Application*: IHC

Recombinant Mouse Anti-CD163 Antibody (CBHb388) (CBMAB-Hb236-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBHb388
Application*: FC, IHC-F, IF, IP, IHC-P, WB

Recombinant Mouse Anti-CD163 Antibody (CBHb225) (CBMAB-Hb235-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBHb225
Application*: FC, IHC-F, FuncS, IF, IP, WB

Mouse Anti-CD163 Recombinant Antibody (IHC163) (CBMAB-MA033-YC)

Datasheet SDS
Target: CD163
Host: Mouse
Specificity: Human
Clone: IHC163
Application*: IH

Rabbit Anti-CD163 Recombinant Antibody (D6U1J) (CBMAB-CP0179-LY)

Datasheet SDS
Target: CD163
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6U1J
Application*: WB, IH, P

Mouse Anti-CD163 Recombinant Antibody (MM0161-6J58) (CBMAB-C10016-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0161-6J58
Application*: WB, F

Mouse Anti-CD163 Recombinant Antibody (ED2) (CBMAB-C10009-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: ED2
Application*: F

Mouse Anti-CD163 Recombinant Antibody (TS106) (CBMAB-C10013-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TS106
Application*: E

Mouse Anti-CD163 Recombinant Antibody (2A10-11) (CBMAB-C10014-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 2A10-11
Application*: F

Mouse Anti-CD163 Recombinant Antibody (MAC2-158) (CBMAB-C10010-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MAC2-158
Application*: F

Rabbit Anti-CD163 Recombinant Antibody (CBNH-018) (CBMAB-R4343-CN)

Datasheet SDS
Target: CD163
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-018
Application*: E, IH, F

Mouse Anti-CD163 Recombinant Antibody (14L167) (CBMAB-C1538-CN)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L167
Application*: FC, WB

Mouse Anti-CD163 Recombinant Antibody (CBYY-C1201) (CBMAB-C2638-YY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1201
Application*: F, WB

Mouse Anti-CD163 Recombinant Antibody (CBYY-C1200) (CBMAB-C2637-YY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-C1200
Application*: E, F, IF, IH, IP, WB

Mouse Anti-CD163 Recombinant Antibody (CBYY-C1198) (CBMAB-C2635-YY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1198
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (CBYY-C1197) (CBMAB-C2634-YY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C1197
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (CBYY-C1196) (CBMAB-C2633-YY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1196
Application*: IF, WB

Mouse Anti-CD163 Recombinant Antibody (6J58) (CBMAB-C8369-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6J58
Application*: C, WB

Mouse Anti-CD163 Recombinant Antibody (6D3.2F3) (CBMAB-C8199-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 6D3.2F3
Application*: WB, F, IH, P

Mouse Anti-CD163 Recombinant Antibody (6A520) (CBMAB-C8047-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6A520
Application*: E, F, IF, IH, IP, WB

Mouse Anti-CD163 Recombinant Antibody (5C6-FAT) (CBMAB-C7404-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C6-FAT
Application*: F, C, E, WB, P

Mouse Anti-CD163 Recombinant Antibody (4G8) (CBMAB-C7018-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G8
Application*: IF, WB

Mouse Anti-CD163 Recombinant Antibody (3D4) (CBMAB-C5875-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D4
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (3C4) (CBMAB-C5810-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3C4
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (3C1) (CBMAB-C5768-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C1
Application*: IF, WB

Mouse Anti-CD163 Recombinant Antibody (3B4) (CBMAB-C5718-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B4
Application*: WB, P, IC/IF

Mouse Anti-CD163 Recombinant Antibody (2G12) (CBMAB-C5151-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G12
Application*: WB, P, IC/IF

Mouse Anti-CD163 Recombinant Antibody (2F8) (CBMAB-C5119-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2F8
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (2C1) (CBMAB-C4735-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1
Application*: IF, WB

Mouse Anti-CD163 Recombinant Antibody (2B12) (CBMAB-C4665-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B12
Application*: WB, P, IF/IC

Mouse Anti-CD163 Recombinant Antibody (1H1) (CBMAB-C4213-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1H1
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (1D5) (CBMAB-C3841-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D5
Application*: IF, P, WB

Mouse Anti-CD163 Recombinant Antibody (1B4) (CBMAB-C3645-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: WB, P, IF/IC

Mouse Anti-CD163 Recombinant Antibody (11n43) (CBMAB-C2549-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11n43
Application*: E

Mouse Anti-CD163 Recombinant Antibody (10D6) (CBMAB-C2299-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10D6
Application*: P

Mouse Anti-CD163 Recombinant Antibody (215930) (CBMAB-C0632-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 215930
Application*: EC

Mouse Anti-CD163 Recombinant Antibody (215901) (CBMAB-C0631-LY)

Datasheet SDS
Target: CD163
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 215901
Application*: WB, F, MC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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