Sign in or Register

loading...

CD163

CD163 (CD163 Molecule) is a Protein Coding gene. Diseases associated with CD163 include Rosai-Dorfman Disease and Non-Langerhans-Cell Histiocytosis. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is CD163L1.

Full Name

CD163 Molecule

Function

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Biological Process

Acute-phase response Source: UniProtKB-KW
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Receptor-mediated endocytosis Source: Reactome

Cellular Location

Secreted; Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Topology

Extracellular: 42-1050
Helical: 1051-1071
Cytoplasmic: 1072-1156

PTM

A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
Phosphorylated.

View more

Anti-CD163 antibodies

+ Filters

Loading...

Mouse Anti-CD163 Recombinant Antibody (CBT3846) (V2LY-0625-LY1341)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3846

Application*: WB, IH, F

Mouse Anti-CD163 Recombinant Antibody (CBT3009) (V2LY-0625-LY1340)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3009

Application*: F

Mouse Anti-CD163 Recombinant Antibody (ED2) (CBMAB-C10009-LY)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse, Rat

Clone: ED2

Application*: F, IF, P, IP, WB

Rabbit Anti-CD163 Recombinant Antibody (CBNH-018) (CBMAB-R4343-CN)

Compare

Target: CD163

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: CBNH-018

Application*: WB, IH, F, IF

Mouse Anti-CD163 Recombinant Antibody (RM3/1) (CBMAB-C5497-CQ)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: RM3/1

Application*: F, P, IF

Mouse Anti-CD163 Recombinant Antibody (GHI/61) (CBMAB-C0676-CQ)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: GHI/61

Application*: F, IF, P, IP, WB

Mouse Anti-CD163 Recombinant Antibody (CBFYC-1118) (CBMAB-C1176-FY)

Compare

Target: CD163

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBFYC-1118

Application*: WB, IF

Mouse Anti-CD163 Recombinant Antibody (CBFYC-0514) (CBMAB-C0565-FY)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0514

Application*: P

Mouse Anti-CD163 Recombinant Antibody (CBFYC-0444) (CBMAB-C0490-FY)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0444

Application*: P

Mouse Anti-CD163 Recombinant Antibody (6D3.2F3) (CBMAB-C8199-LY)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 6D3.2F3

Application*: WB, F, IH

Mouse Anti-CD163 Recombinant Antibody (5C6-FAT) (CBMAB-C7404-LY)

Compare

Target: CD163

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5C6-FAT

Application*: WB, E, F, IF, IH

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion

IEImmunoelectrophoresis
IFImmunofluorescence
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry