CNGA2

CNGA3 (Cyclic Nucleotide Gated Channel Alpha 3) is a Protein Coding gene. Diseases associated with CNGA3 include Achromatopsia 2 and Achromatopsia. Among its related pathways are cAMP signaling pathway and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and voltage-gated potassium channel activity. An important paralog of this gene is CNGA1.

Full Name

Cyclic Nucleotide Gated Channel Alpha 2

Function

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Biological Process

Cilium assembly Source: Reactome
Response to stimulus Source: UniProtKB-KW
Sensory perception of smell Source: UniProtKB-KW

Cellular Location

Membrane

Topology

Cytoplasmic: 1-138
Helical: 139-159
Extracellular: 160-171
Helical: 172-192
Cytoplasmic: 193-224
Helical: 225-245
Extracellular: 246-274
Helical: 275-295
Cytoplasmic: 296-350
Helical: 351-371
Extracellular: 372-453
Helical: 454-474
Cytoplasmic: 475-662