CRB3

CRB3 (Crumbs 3, Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with CRB3 include Leber Congenital Amaurosis 8 and Leber Congenital Amaurosis. Among its related pathways are Notch Signaling Pathway (sino) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SH3 domain binding.

Full Name

Crumbs 3, Cell Polarity Complex Component

Function

Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572).

Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572).

Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).

Biological Process

Bicellular tight junction assembly Source: Reactome
Positive regulation of cell junction assembly Source: UniProtKB
Protein localization to plasma membrane Source: BHF-UCL

Cellular Location

Apical cell membrane; Tight junction. Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.

Topology

Extracellular: 27-59
Helical: 60-80
Cytoplasmic: 81-120