CSNK1D

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

casein kinase 1, delta

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Ciliary basal body-plasma membrane docking Source: Reactome
Circadian regulation of gene expression Source: UniProtKB
COPII vesicle coating Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Golgi organization Source: SYSCILIA_CCNET
Microtubule nucleation Source: SYSCILIA_CCNET
Non-motile cilium assembly Source: SYSCILIA_CCNET
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Protein localization to centrosome Source: SYSCILIA_CCNET
Protein localization to cilium Source: SYSCILIA_CCNET
Protein localization to Golgi apparatus Source: SYSCILIA_CCNET
Protein phosphorylation Source: UniProtKB
Regulation of circadian rhythm Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Spindle assembly Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cytoplasm; Nucleus; Golgi apparatus; Cell membrane; Centrosome; Spindle; Perinuclear region. Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.

Advanced sleep phase syndrome, familial, 2 (FASPS2):
A disorder characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.

Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.