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DIABLO

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Full Name
Diablo homolog, mitochondrial
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: GO_Central
Apoptotic process Source: ProtInc
Extrinsic apoptotic signaling pathway via death domain receptors Source: ProtInc
Intrinsic apoptotic signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to oxidative stress Source: GO_Central
Neuron apoptotic process Source: GO_Central
Positive regulation of apoptotic process Source: UniProtKB
Cellular Location
Mitochondrion. Released into the cytosol when cells undergo apoptosis.
Involvement in disease
Deafness, autosomal dominant, 64 (DFNA64):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Ubiquitinated by BIRC7/livin.

Anti-DIABLO antibodies

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Rabbit Anti-DIABLO Recombinant Antibody (CBXS-6185) (CBMAB-S6501-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-6185
Application*: WB, IH

Rat Anti-DIABLO Recombinant Antibody (CBXS-3361) (CBMAB-S6098-CQ)

Datasheet SDS
Target: DIABLO
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-3361
Application*: E, F, IC, IH, IP, WB

Rat Anti-DIABLO Recombinant Antibody (CBXS-3360) (CBMAB-S6097-CQ)

Datasheet SDS
Target: DIABLO
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-3360
Application*: E, F, IC, IP, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3326) (CBMAB-S6064-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3326
Application*: E, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3265) (CBMAB-S6006-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBXS-3265
Application*: IC, IF, IH, IP, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3234) (CBMAB-S5975-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3234
Application*: E, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3147) (CBMAB-S5889-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3147
Application*: WB

Mouse Anti-DIABLO Recombinant Antibody (2D12) (CBMAB-D0868-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2D12
Application*: E, WB

Mouse Anti-DIABLO Recombinant Antibody (3J21) (CBMAB-D0869-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3J21
Application*: WB

Mouse Anti-DIABLO Recombinant Antibody (78-1-118) (CBMAB-D0870-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 78-1-118
Application*: IC, IF, IP, WB

Mouse Anti-DIABLO Recombinant Antibody (79-1-83) (CBMAB-D0871-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 79-1-83
Application*: WB, IH

Mouse Anti-DIABLO Recombinant Antibody (8H5AA3) (CBMAB-D0872-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8H5AA3
Application*: IC

Mouse Anti-DIABLO Recombinant Antibody (8H5AB2) (CBMAB-D0873-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8H5AB2
Application*: WB

Mouse Anti-DIABLO Recombinant Antibody (AT19F2) (CBMAB-D0874-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AT19F2
Application*: E, WB

Mouse Anti-DIABLO Recombinant Antibody (SMAC 171-87) (CBMAB-D0875-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: SMAC 171-87
Application*: IC, IF, P, IP, WB

Rat Anti-DIABLO Recombinant Antibody (10G7) (CBMAB-D0876-YC)

Datasheet SDS
Target: DIABLO
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 10G7
Application*: IF, IP, WB

Mouse Anti-DIABLO Recombinant Antibody (4F9) (CBMAB-D0877-YC)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F9
Application*: E, WB

Rat Anti-DIABLO Recombinant Antibody (9H10) (CBMAB-D0878-YC)

Datasheet SDS
Target: DIABLO
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 9H10
Application*: C, IF, IP, P, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-5873) (CBMAB-S0725-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5873
Application*: WB, E

Mouse Anti-DIABLO Recombinant Antibody (CBXS-5939) (CBMAB-S0788-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5939
Application*: P, IC, F

Rat Anti-DIABLO Recombinant Antibody (CBXS-3630) (CBMAB-S0912-CQ)

Datasheet SDS
Target: DIABLO
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3630
Application*: E, F, IC, IP, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3665) (CBMAB-S0944-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3665
Application*: IF, IF

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3775) (CBMAB-S1047-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBXS-3775
Application*: WB, IP, IF

Mouse Anti-DIABLO Recombinant Antibody (CBXS-4483) (CBMAB-S1725-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4483
Application*: E, WB

Mouse Anti-DIABLO Recombinant Antibody (CBXS-5514) (CBMAB-S2722-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: CBXS-5514
Application*: WB, E, IC

Rabbit Anti-DIABLO Recombinant Antibody (CBXS-1265) (CBMAB-S4124-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1265
Application*: WB, P

Rabbit Anti-DIABLO Recombinant Antibody (CBXS-1066) (CBMAB-S3957-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1066
Application*: F

Mouse Anti-DIABLO Recombinant Antibody (CBXS-3785) (CBMAB-S0222-CQ)

Datasheet SDS
Target: DIABLO
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3785
Application*: WB, E

Rabbit Anti-DIABLO Recombinant Antibody (CBXS-4248) (CBMAB-S1500-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4248
Application*: E

Rabbit Anti-DIABLO Recombinant Antibody (CBXS-5199) (CBMAB-S2416-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5199
Application*: E, WB

Rabbit Anti-DIABLO Recombinant Antibody (CBXS-1040) (CBMAB-S3933-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1040
Application*: IP

Rabbit Anti-DIABLO Recombinant Antibody (CBXS-1060) (CBMAB-S3951-CQ)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1060
Application*: WB, E, IF, IF

Rabbit Anti-DIABLO Recombinant Antibody (D5S3R) (CBMAB-CP2486-LY)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D5S3R
Application*: WB, IP, P, IF (IC), F

Rabbit Anti-DIABLO Recombinant Antibody (RM271) (CBMAB-BR158LY)

Datasheet SDS
Target: DIABLO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM271
Application*: IHC, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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