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Mouse Anti-DIABLO Recombinant Antibody (SMAC 171-87) (CBMAB-D0875-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Diablo IAP-Binding Mitochondrial Protein (DIABLO). The antibody can be used for immunoassay techniques, such as ICC, IF, IHC-P, IP, WB.
See all DIABLO antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
SMAC 171-87
Antibody Isotype
IgG1
Application
ICC, IF, IHC-P, IP, WB

Basic Information

Immunogen
C-Terminal His tagged recombinant human Smac/DIABLO
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Diablo homolog, mitochondrial
Introduction
Diablo is an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
Human56616
Mouse66593
Rat288753
UniProt ID
HumanQ9NR28
MouseQ9JIQ3
RatQ5RK17
Alternative Names
Diablo IAP-Binding Mitochondrial Protein; Second Mitochondria-Derived Activator Of Caspase; Direct IAP-Binding Protein With Low PI; SMAC; Diablo, IAP-Binding Mitochondrial Protein; Diablo Homolog, Mitochondrial; Diablo-Like Protein; DFNA64;
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: GO_Central
Apoptotic process Source: ProtInc
Extrinsic apoptotic signaling pathway via death domain receptors Source: ProtInc
Intrinsic apoptotic signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to oxidative stress Source: GO_Central
Neuron apoptotic process Source: GO_Central
Positive regulation of apoptotic process Source: UniProtKB
Cellular Location
Mitochondrion. Released into the cytosol when cells undergo apoptosis.
Involvement in disease
Deafness, autosomal dominant, 64 (DFNA64):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Ubiquitinated by BIRC7/livin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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