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F13A1

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Full Name
Coagulation Factor XIII A Chain
Research Area
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Biological Process
Blood coagulation Source: ProtInc
Blood coagulation, fibrin clot formation Source: UniProtKB
Peptide cross-linking Source: UniProtKB
Cellular Location
Secreted; Cytoplasm. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Involvement in disease
Factor XIII subunit A deficiency (FA13AD):
An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
PTM
The activation peptide is released by thrombin.
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Anti-F13A1 antibodies

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Mouse Anti-F13A1 Recombinant Antibody (CB49A) (CBMAB-CA049LY)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB49A
Application*: WB, P, F
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (M1) (V2LY-0825-LY1074)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: M1
Application*: E, PLA
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (F2148) (V2LY-0825-LY1072)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: F2148
Application*: IH
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (CBXF-2287) (V2LY-0825-LY1070)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-2287
Application*: WB, E, F, IF, IH
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (CBXF-2286) (V2LY-0825-LY1069)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2286
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (F1655) (V2LY-0825-LY1068)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: F1655
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (CBXF-0147) (V2LY-0825-LY1067)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-0147
Application*: WB, IH
Datasheet SDS

Rabbit Anti-F13A1 Recombinant Antibody (CBXF-1073) (V2LY-0825-LY1065)

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Target: F13A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1073
Application*: WB, IH
Datasheet SDS

F13A1 Matched Antibody Pair (395) (APMAB-395LY)

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Target: F13A1
Specificity: Human
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (2B2) (CBMAB-AP2165LY)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2B2
Application*: WB, IH
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (CBXF-3769) (CBMAB-F2382-CQ)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3769
Application*: WB, P, F
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (CBXF-3551) (CBMAB-F2092-CQ)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3551
Application*: F, WB, P, IF
Datasheet SDS

Mouse Anti-F13A1 Recombinant Antibody (CBXF-0146) (CBMAB-F1419-CQ)

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0146
Application*: WB, E
Datasheet SDS

Rabbit Anti-F13A1 Recombinant Antibody (EP3372) (CBMAB-R0025-FY)

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Target: F13A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP3372
Application*: WB, IH, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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