FCRL1

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants.

Fc Receptor Like 1

May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.

B cell activation Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central

Cell membrane

Extracellular: 17-307
Helical: 308-328
Cytoplasmic: 329-429

Phosphorylated on tyrosines upon activation.