FCRL1
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants.
Full Name
Fc Receptor Like 1
Research Area
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
Biological Process
B cell activation Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 17-307
Helical: 308-328
Cytoplasmic: 329-429
Helical: 308-328
Cytoplasmic: 329-429
PTM
Phosphorylated on tyrosines upon activation.
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Anti-FCRL1 antibodies
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Target: FCRL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1734
Application*: WB
Target: FCRL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0480
Application*: WB, F
Target: FCRL1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-3304
Application*: F
Target: FCRL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2593
Application*: WB, IP, IF, E
Target: FCRL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-3305
Application*: WB, IP, IF, E
Target: FCRL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4551
Application*: F
Target: FCRL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2933
Application*: F
Target: FCRL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0848
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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