FGR
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Full Name
FGR Proto-Oncogene, Src Family Tyrosine Kinase
Function
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity).
Biological Process
Bone mineralization Source: Ensembl
Cell differentiation Source: GO_Central
Defense response to Gram-positive bacterium Source: UniProtKB
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
Innate immune response Source: GO_Central
Integrin-mediated signaling pathway Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of natural killer cell activation Source: Ensembl
Peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: ProtInc
Regulation of cell shape Source: UniProtKB
Regulation of innate immune response Source: UniProtKB
Regulation of phagocytosis Source: UniProtKB
Regulation of protein kinase activity Source: UniProtKB
Response to virus Source: ProtInc
Skeletal system morphogenesis Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cell differentiation Source: GO_Central
Defense response to Gram-positive bacterium Source: UniProtKB
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
Innate immune response Source: GO_Central
Integrin-mediated signaling pathway Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of natural killer cell activation Source: Ensembl
Peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: ProtInc
Regulation of cell shape Source: UniProtKB
Regulation of innate immune response Source: UniProtKB
Regulation of phagocytosis Source: UniProtKB
Regulation of protein kinase activity Source: UniProtKB
Response to virus Source: ProtInc
Skeletal system morphogenesis Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Cytoskeleton; Mitochondrion inner membrane; Mitochondrion intermembrane space; Cytosol; Cell membrane; Cell membrane; Ruffle membrane. Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts.
Involvement in disease
Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
PTM
Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.
Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
View more
Anti-FGR antibodies
Products List
+ Filters
Loading...
CompareTarget: FGR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 1B12
Application*: E, IH, WB
Target: FGR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBWJC-3700
Application*: E, IH, WB
Target: FGR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-1591
Application*: E, IH, WB
Target: FGR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3005
Application*: IF
Target: FGR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXF-3004
Application*: WB
Target: FGR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXF-2638
Application*: WB, E, IH
Target: FGR
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G10
Application*: WB, E
Target: FGR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBXF-0651
Application*: WB, IP, IF, E
Target: FGR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0652
Application*: WB, IP, IF, E
Target: FGR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-391
Application*: WB, IP, IF, E
Target: FGR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-3699
Application*: E, IH, WB
Target: FGR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0650
Application*: WB, E, IH
Target: FGR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBT238
Application*: WB, P, IF, E
Target: FGR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3492
Application*: WB, IH
More Infomation
Hot products 
-
Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-007) (CBMAB-Z0012-WJ)
-
Mouse Anti-CD24 Recombinant Antibody (SN3) (CBMAB-C1037-CQ)
-
Mouse Anti-CALR Recombinant Antibody (CBFYC-0763) (CBMAB-C0818-FY)
-
Rat Anti-4-1BB Recombinant Antibody (V2-1558) (CBMAB-0953-LY)
-
Mouse Anti-CD33 Recombinant Antibody (P67.6) (CBMAB-C10189-LY)
-
Mouse Anti-ATM Recombinant Antibody (2C1) (CBMAB-A3970-YC)
-
Mouse Anti-CDK7 Recombinant Antibody (CBYY-C1783) (CBMAB-C3221-YY)
-
Mouse Anti-CASP8 Recombinant Antibody (CBYY-C0987) (CBMAB-C2424-YY)
-
Mouse Anti-CCDC6 Recombinant Antibody (CBXC-0106) (CBMAB-C5397-CQ)
-
Rabbit Anti-ALDOA Recombinant Antibody (D73H4) (CBMAB-A2314-YC)
-
Mouse Anti-FOSB Recombinant Antibody (CBXF-3593) (CBMAB-F2522-CQ)
-
Mouse Anti-BHMT Recombinant Antibody (CBYY-0547) (CBMAB-0550-YY)
-
Rabbit Anti-AKT3 Recombinant Antibody (V2-12567) (CBMAB-1057-CN)
-
Mouse Anti-AMOT Recombinant Antibody (CBYC-A564) (CBMAB-A2552-YC)
-
Rabbit Anti-ADRA1A Recombinant Antibody (V2-12532) (CBMAB-1022-CN)
-
Mouse Anti-BIRC3 Recombinant Antibody (16E63) (CBMAB-C3367-LY)
-
Mouse Anti-GFP Recombinant Antibody (28) (CBMAB-G3038-LY)
-
Mouse Anti-CCS Recombinant Antibody (CBFYC-1093) (CBMAB-C1150-FY)
-
Rabbit Anti-B2M Recombinant Antibody (CBYY-0059) (CBMAB-0059-YY)
-
Mouse Anti-APC Recombinant Antibody (CBYC-A661) (CBMAB-A3036-YC)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry