FHOD1

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq]

Full Name

formin homology 2 domain containing 1

Function

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.

Biological Process

Actin filament network formation Source: GO_Central
Cortical actin cytoskeleton organization Source: GO_Central
Establishment of centrosome localization Source: Ensembl
Nuclear migration Source: Ensembl
Positive regulation of stress fiber assembly Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of stress fiber assembly Source: CAFA

Cellular Location

Cytoplasm; Cytoskeleton; Bleb. Predominantly cytoplasmic.

PTM

Phosphorylated by ROCK1.