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FHOD1

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq]
Full Name
formin homology 2 domain containing 1
Function
Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.
Biological Process
Actin filament network formation Source: GO_Central
Cortical actin cytoskeleton organization Source: GO_Central
Establishment of centrosome localization Source: Ensembl
Nuclear migration Source: Ensembl
Positive regulation of stress fiber assembly Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of stress fiber assembly Source: CAFA
Cellular Location
Cytoplasm; Cytoskeleton; Bleb. Predominantly cytoplasmic.
PTM
Phosphorylated by ROCK1.
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Anti-FHOD1 antibodies

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Mouse Anti-FHOD1 Recombinant Antibody (3F7) (CBMAB-A2986-LY)

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Target: FHOD1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F7
Application*: WB, E
Datasheet SDS

Mouse Anti-FHOD1 (AA 2-99) Recombinant Antibody (CBXF-3028) (CBMAB-F3734-CQ)

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Target: FHOD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3028
Application*: E, WB
Datasheet SDS

Mouse Anti-FHOD1 Recombinant Antibody (CBXF-1942) (CBMAB-F1522-CQ)

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Target: FHOD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-1942
Application*: WB, IF
Datasheet SDS

Mouse Anti-FHOD1 Recombinant Antibody (CBXF-0681) (CBMAB-F1484-CQ)

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Target: FHOD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0681
Application*: WB, E, IH
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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