GATC

In Escherichia coli the methylation of the adenine in the sequence 5′-GATC-3′ is catalysed by the dam gene product, a DNA adenine methylase.

Full Name

glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)

Function

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Biological Process

Glutaminyl-tRNAGln biosynthesis via transamidation Source: UniProtKB
Mitochondrial translation Source: UniProtKB
Regulation of translational fidelity Source: InterPro

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 42 (COXPD42):
An autosomal recessive mitochondrial disorder characterized by onset in the first months of life, cardiomyopathy, respiratory insufficiency, lactic acidosis, anemia, and variable impairment of mitochondrial respiratory complexes I, III, and IV. Death occurs in infancy.

Anti-GATC antibodies

Mouse Anti-GATC Recombinant Antibody (3G9) (CBMAB-A3312-LY)

Datasheet

SDS

Target: GATC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G9

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)