GATC

In Escherichia coli the methylation of the adenine in the sequence 5′-GATC-3′ is catalysed by the dam gene product, a DNA adenine methylase.

Full Name

glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)

Function

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Biological Process

Glutaminyl-tRNAGln biosynthesis via transamidation Source: UniProtKB
Mitochondrial translation Source: UniProtKB
Regulation of translational fidelity Source: InterPro

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 42 (COXPD42):
An autosomal recessive mitochondrial disorder characterized by onset in the first months of life, cardiomyopathy, respiratory insufficiency, lactic acidosis, anemia, and variable impairment of mitochondrial respiratory complexes I, III, and IV. Death occurs in infancy.